Is the ubiquitous herbicide, glyphosate, about to have its moment of reckoning? The Government’s renewal assessment of the chemical was expected in 2026. However, the UK is now negotiating a trade agreement with the EU. Dynamic alignment on pesticides regulation between the UK and EU puts the fate of glyphosate into question, particularly for pre-harvest desiccation. Meanwhile, understanding of glyphosate resistance and its negative human and environmental health impacts improves. Our interdisciplinary panel brings together academic, policy and farming views to ask: What is the true cost of another glyphosate approval? Are there real alternatives to glyphosate for nature-friendly farmers?